Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

Borrelia burgdorferi, a pathogen transmitted by Ixodes ticks, is responsible for a prevalent
illness known as Lyme disease, and a vaccine for human use is unavailable. Recently …

Activity-based protein profiling (ABPP) is a chemoproteomic tool for detecting active
enzymes in complex biological systems. We used ABPP to identify secreted bacterial and …

In Borrelia burgdorferi, BB0556 was annotated as a conserved hypothetical protein. We
herein investigated gene expression and the importance of this protein during infection. Our …

Abstract Changes in cellular metabolism have proven to be important factors in driving cell
behavior. It has been shown that cellular metabolism of immune cells changes when …

Borrelia burgdorferi, the vector-borne bacterium that causes Lyme disease, was first
identified in 1982. It is known that much of the pathology associated with Lyme borreliosis is …

The Lyme disease spirochete Borrelia burgdorferi relies on uptake of essential nutrients
from its host environments for survival and infection. Therefore, nutrient acquisition …

Abstract The spirochetes Borrelia (Borreliella) burgdorferi and Borrelia hermsii, the etiologic
agents of Lyme disease and relapsing fever, respectively, cycle in nature between an …

Borrelia burgdorferi is a spirochetal bacterium transmitted by the Ixodes tick that causes
Lyme disease in humans due to its ability to evade the host immune response and …