A role for microfluidic systems in precision medicine
JM Ayuso, M Virumbrales-Muñoz, JM Lang… - Nature …, 2022 - nature.com
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
Mechanisms of cancer metastasis
M Castaneda, P den Hollander, NA Kuburich… - Seminars in cancer …, 2022 - Elsevier
Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …
[HTML][HTML] 3D in vitro model (R) evolution: unveiling tumor–stroma interactions
The complex microenvironment in which malignant tumor cells grow is crucial for cancer
progression. The physical and biochemical characteristics of this niche are involved in …
progression. The physical and biochemical characteristics of this niche are involved in …
Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …
Could 3D models of cancer enhance drug screening?
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
Recent advances in lung-on-a-chip models
Highlights•Transition from conventional 2D models to 3D and advanced lung-on-a-chip
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …
Recent innovations in cost-effective polymer and paper hybrid microfluidic devices
Hybrid microfluidic systems that are composed of multiple different types of substrates have
been recognized as a versatile and superior platform, which can draw benefits from different …
been recognized as a versatile and superior platform, which can draw benefits from different …
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed,
several microdevices are being developed specifically for clinical use to test novel cancer …
several microdevices are being developed specifically for clinical use to test novel cancer …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …