Prostanoids are cyclic, oxygenated products ofω3 andω6 20-and 22-carbon essential fatty
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …

Cyclooxgenases are key enzymes of lipid signaling. They carry out the first step in the
production of prostaglandins, important mediators of inflammation, pain, cardiovascular …

Cell membranes contain hundreds of different proteins and lipids in an asymmetric
arrangement. Our current understanding of the detailed organization of cell membranes …

Paracetamol has a central analgesic effect that is mediated through activation of descending
serotonergic pathways. Debate exists about its primary site of action, which may be …

A procedure for analyzing and classifying publicly available crystal structures has been
developed. It has been used to identify high-resolution protein− ligand complexes that can …

Cancer is a leading cause of death worldwide. Even after the availability of numerous drugs
and treatments in the market, scientists and researchers are focusing on new therapies …

Oxicams are a class of nonsteroidal anti‐inflammatory drugs (NSAIDs) structurally related to
the enolic acid class of 4‐hydroxy‐1, 2‐benzothiazine carboxamides. They are used …

Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due
to growing evidence of their significant role in cancer biology. Thus, inhibitors of the AA …

Computer simulations are rapidly becoming a standard tool to study the structure and
dynamics of lipids and membrane proteins. Increasing computer capacity allows unbiased …

Prostaglandin endoperoxide H synthases (PGHSs)-1 and-2 (also called cyclooxygenases
(COXs)-1 and-2) catalyze the committed step in prostaglandin biosynthesis. Both isoforms …