Prominent features of atheromata include smooth muscle cells, cholesteryl ester-loaded
macrophage foam cells, extracellular matrix, extracellularly trapped and aggregated …

Atherosclerotic lesions contain an extracellular sphingomyelinase (SMase) activity that
hydrolyzes the sphingomyelin of subendothelial low density lipoprotein (LDL). This SMase …

Increased in vitro platelet aggregability and hypercoagulability are generally held to be main
determinants in the prethrombotic state in nephrosis. In vivo, however, thrombotic events …

Plasma fibronectin (pFN) cross-linked to fibrin during the injury response provides a
provisional matrix required for cells to begin tissue repair. Using a synthetic matrix of pFN …

Collagen type IV is a sheet-forming collagen and a major constituent of the vessel wall. To
find out which conditions are important for platelet adhesion to collagen type IV, we …

Platelet adhesion to fibrin at high shear rates depends on both the glycoprotein (GP) IIb: IIIa
complex and a secondary interaction between GPIb and von Willebrand factor (vWF). This …

The macromolecular composition of the extracellular matrix (ECM) produced by the human
microvascular endothelial cell line (HMEC-1) was determined by ELISA and its …

Platelet thrombus formation on collagen is initiated by platelet GPIb interaction with von
Willebrand factor (vWF) bound to collagen, followed by firm attachment of the platelet to …

Glycoprotein (GP) Ib is an adhesion receptor on the platelet surface that binds to von
Willebrand Factor (vWF). vWF becomes attached to collagens and other adhesive proteins …

Platelets at injured vessel wall form an adhesive surface for leukocyte adhesion. The precise
relation between platelet adhesion and activation and leukocyte adhesion, however, is not …