Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Background Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-
to-cell communication including shuttle RNA, mainly mRNA and microRNA. As exosomes …

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …

Synthetic lethality is a powerful approach to study selective cell killing based on genotype.
We show that loss of Rad52 function is synthetically lethal with breast cancer 2, early onset …

Some immortalized mammalian cell lines and tumors maintain or increase the overall length
of their telomeres in the absence of telomerase activity by one or more mechanisms referred …

Maintenance of genomic integrity and stable transmission of genetic information depend on
a number of DNA repair processes. Failure to faithfully perform these processes can result in …

The Rad51 protein, a eukaryotic homologue of Escherichia coli RecA, plays a central role in
both mitotic and meiotic homologous DNA recombination (HR) in Saccharomyces cerevisiae …

Saccharomyces cerevisiae RAD50 and MRE11 genes are required for the nucleolytic
processing of DNA double-strand breaks. We have overexpressed Rad50 and Mre11 in …

DNA double-strand breaks (DSB) are presumed to be the most deleterious DNA lesions as
they disrupt both DNA strands. Homologous recombination (HR), single-strand annealing …