Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Although many studies have been exploring the mechanisms driving NETs formation, much
less attention has been paid to the degradation and elimination of these structures. The …

The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD)
activity have been observed in several neurodegenerative diseases. PC is a …

Objective Anti–citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid
arthritis (RA) and have long been regarded as pathogenic. Despite substantial in vitro …

Despite the importance of citrullination in physiology and disease, global identification of
citrullinated proteins, and the precise targeted sites, has remained challenging. Here we …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Here we report preliminary data demonstrating that some patients with myalgic
encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies …