More than half of the initially-formed neurons are deleted in certain brain regions during
normal development. This process, whereby cells are discretely removed without interfering …

Since the discovery by this laboratory of the zinc finger transcription factor, KLF10, a member
of the Krüppel-like family of transcription factors, there have been multiple publications …

The tuberous sclerosis proteins TSC1 and TSC2 are key integrators of growth factor
signaling. They suppress cell growth and proliferation by acting in a heteromeric complex to …

We investigated the influence of transforming growth factor-β (TGF-β) signaling on
developmental programmed cell death in the mouse retina by direct and specific molecular …

Proinsulin has been characterized as a neuroprotective molecule. In this work we assess the
therapeutic potential of proinsulin on photoreceptor degeneration, synaptic connectivity, and …

purpose. Retinitis pigmentosa (RP) is a heterogeneous group of inherited conditions that
lead to blindness and for which there is no effective therapy. Apoptosis of photoreceptors is …

Purpose Intravitreal insulin has been shown to be a powerful stimulator of myopia in
chickens, in particular if the retinal image is degraded or defocused. In most tissues, the …

Preclinical toxicity screening of the new retinal compounds is an absolute requirement in the
pathway of further drug development. Since retinal neuron cultivation and in vivo studies are …

A novel organotypic culture method of mouse retina explants is being introduced and
characterized to evaluate its usefulness in studying glutamate excitotoxicity. Retinal whole …

Programmed cell death is a genuine developmental process of the nervous system, affecting
not only projecting neurons but also proliferative neuroepithelial cells and young …