Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

Every biological trait requires both a proximate and evolutionary explanation. The field of
vascular biology is focused primarily on proximate mechanisms in health and disease …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Cell types are the basic building units of multicellular life, with extensive diversities. The
evolution of cell types is a crucial layer of comparative cell biology but is thus far not …

The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Atherosclerosis is one of the key problems of modern medicine, which is due to the high
prevalence of atherosclerotic cardiovascular diseases and their significant share in the …

The evolution of the vertebrate liver is a prime example of the evolution of complex organs,
yet the driving genetic factors behind it remain unknown. Here we study the evolutionary …

FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior,
energy balance, and reproduction. Here, we show that FMRFamide signaling from the …

Echinoderms, an ancient and very successful phylum of marine invertebrates, play a central
role in the maintenance of ecosystem integrity and are constantly exposed to environmental …

Myocardial injury as induced by myocardial infarction results in tissue ischemia, which
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …