Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two
major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a …

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …

Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …

Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …

Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage
of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely …

Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied
in diverse inflammatory disease models. Membrane perforation and cell swelling induced by …

Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …

Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, and its incidence is
increasing annually. It is critical to reveal and delineate the molecular mechanism promoting …

Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and
necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin …