Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
Statins: Adverse reactions, oxidative stress and metabolic interactions
A Liu, Q Wu, J Guo, I Ares, JL Rodríguez… - Pharmacology & …, 2019 - Elsevier
Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are currently
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …
Mechanisms of drug-induced liver injury
C Stephens, RJ Andrade… - Current opinion in allergy …, 2014 - journals.lww.com
Idiosyncratic DILI development is believed to be orchestrated by multiple events, such as
reactive metabolite formations, oxidative stress and signalling pathway inductions, with the …
reactive metabolite formations, oxidative stress and signalling pathway inductions, with the …
Increased liver-specific proteins in circulating extracellular vesicles as potential biomarkers for drug-and alcohol-induced liver injury
Drug-and alcohol-induced liver injury are a leading cause of liver failure and transplantation.
Emerging evidence suggests that extracellular vesicles (EVs) are a source of biomarkers …
Emerging evidence suggests that extracellular vesicles (EVs) are a source of biomarkers …
Extracellular vesicles as potential biomarkers for alcohol-and drug-induced liver injury and their therapeutic applications
Extracellular vesicles (EVs) are small membranous vesicles originating from various cells
and tissues, including the liver parenchymal hepatocytes and nonparenchymal cells such as …
and tissues, including the liver parenchymal hepatocytes and nonparenchymal cells such as …
Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice
Exosomes are small extracellular membrane vesicles released from endosomes of various
cells and could be found in most body fluids. The main functions of exosomes have been …
cells and could be found in most body fluids. The main functions of exosomes have been …
An integrated, high-throughput strategy for multiomic systems level analysis
DB Gutierrez, RL Gant-Branum, CE Romer… - Journal of proteome …, 2018 - ACS Publications
Proteomics, metabolomics, and transcriptomics generate comprehensive data sets, and
current biocomputational capabilities allow their efficient integration for systems biology …
current biocomputational capabilities allow their efficient integration for systems biology …
Proteomics in mechanistic toxicology: history, concepts, achievements, caveats, and potential
T Rabilloud, P Lescuyer - Proteomics, 2015 - Wiley Online Library
Toxicoproteomics can be defined as the application of proteomic approaches to the
understanding of toxicology problems, and this review deals with the various types of …
understanding of toxicology problems, and this review deals with the various types of …
Circadian protein expression patterns in healthy young adults
A Specht, G Kolosov, KLJ Cederberg, F Bueno… - Sleep Health, 2024 - Elsevier
Objectives To explore how the blood plasma proteome fluctuates across the 24-hour day
and identify a subset of proteins that show endogenous circadian rhythmicity. Methods …
and identify a subset of proteins that show endogenous circadian rhythmicity. Methods …
Structural effects of simvastatin on rat liver tissue: Fourier transform infrared and Raman microspectroscopic studies
Simvastatin is one of the most frequently prescribed statins because of its efficacy in the
treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality …
treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality …