Beware of docking!

YC Chen - Trends in pharmacological sciences, 2015 - cell.com
Docking is now routine in virtual screening or lead optimization for drug screening and
design. The number of papers related to docking has dramatically increased over the past …

Recent Advances in the Construction of Phosphorus‐Substituted Heterocycles, 2009–2019

L Chen, XY Liu, YX Zou - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
Phosphorus‐substituted heterocycles represent an important class of organophosphorus
compounds, which not only widely exist in biologically active pharmaceuticals …

[HTML][HTML] Development of effective anti-influenza drugs: congeners and conjugates–a review

JJ Shie, JM Fang - Journal of Biomedical Science, 2019 - Springer
Influenza is a long-standing health problem. For treatment of seasonal flu and possible
pandemic infections, there is a need to develop new anti-influenza drugs that have good …

High‐yielding synthesis of the anti‐influenza neuramidase inhibitor (−)‐oseltamivir by three “one‐pot” operations

H Ishikawa, T Suzuki, Y Hayashi - Angewandte Chemie, 2009 - Wiley Online Library
A great deal of attention has been paid both in the scientific literature and the general media
to the high potential risk of a worldwide spread of avian H5N1 influenza virus, the death rate …

Asymmetric organocatalysis in total synthesis–a trial by fire

E Marqués-López, RP Herrera… - Natural Product …, 2010 - pubs.rsc.org
Covering: 2007 to 2009 This review covers the most recent applications of organocatalysis
in the synthesis of natural products and non-natural biologically active molecules. Our aim is …

Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza

J Magano - Chemical reviews, 2009 - ACS Publications
Influenza, a severe viral infection of the respiratory system, is responsible for a significant
morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the …

Ni (II)/Zn catalyzed reductive coupling of aryl halides with diphenylphosphine oxide in water

X Zhang, H Liu, X Hu, G Tang, J Zhu, Y Zhao - Organic Letters, 2011 - ACS Publications
Ni(II)/Zn Catalyzed Reductive Coupling of Aryl Halides with Diphenylphosphine Oxide in Water |
Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters …

Stereoselective Rh2(S-IBAZ)4-Catalyzed Cyclopropanation of Alkenes, Alkynes, and Allenes: Asymmetric Synthesis of Diacceptor Cyclopropylphosphonates and …

VNG Lindsay, D Fiset, PJ Gritsch, S Azzi… - Journal of the …, 2013 - ACS Publications
A mild and highly stereoselective rhodium (II)-catalyzed cyclopropanation of alkenes,
alkynes, and allenes with diacceptor diazo compounds is reported. Using the phosphonate …

[HTML][HTML] Recent progress in chemical approaches for the development of novel neuraminidase inhibitors

A Mahal, M Duan, DS Zinad, RK Mohapatra… - RSC …, 2021 - pubs.rsc.org
Influenza virus is the main cause of an infectious disease called influenza affecting the
respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are …

High‐yielding synthesis of the anti‐influenza neuraminidase inhibitor (−)‐oseltamivir by two “one‐pot” sequences

H Ishikawa, T Suzuki, H Orita… - … A European Journal, 2010 - Wiley Online Library
The efficient asymmetric total synthesis of (−)‐oseltamivir, an antiviral reagent, has been
accomplished by using two “one‐pot” reaction sequences, with excellent overall yield (60%) …