CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome
S Arcangeli, C Bove, C Mezzanotte… - The Journal of …, 2022 - Am Soc Clin Investig
Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to
achieve complete responses and prevent relapses. These features are typical of early …
achieve complete responses and prevent relapses. These features are typical of early …
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies
B Greco, V Malacarne, F De Girardi, GM Scotti… - Science translational …, 2022 - science.org
Immunotherapy with chimeric antigen receptor (CAR)–engineered T cells showed
exceptional successes in patients with refractory B cell malignancies. However, first-in …
exceptional successes in patients with refractory B cell malignancies. However, first-in …
Indefinite proximity learning: A review
FM Schleif, P Tino - Neural computation, 2015 - ieeexplore.ieee.org
Efficient learning of a data analysis task strongly depends on the data representation. Most
methods rely on (symmetric) similarity or dissimilarity representations by means of metric …
methods rely on (symmetric) similarity or dissimilarity representations by means of metric …
[PDF][PDF] Accelerating t-SNE using tree-based algorithms
L Van Der Maaten - The journal of machine learning research, 2014 - jmlr.org
The paper investigates the acceleration of t-SNE—an embedding technique that is
commonly used for the visualization of high-dimensional data in scatter plots—using two …
commonly used for the visualization of high-dimensional data in scatter plots—using two …
Interpretable dimensionality reduction of single cell transcriptome data with deep generative models
Single-cell RNA-sequencing has great potential to discover cell types, identify cell states,
trace development lineages, and reconstruct the spatial organization of cells. However …
trace development lineages, and reconstruct the spatial organization of cells. However …
Data visualization by nonlinear dimensionality reduction
A Gisbrecht, B Hammer - Wiley Interdisciplinary Reviews: Data …, 2015 - Wiley Online Library
In this overview, commonly used dimensionality reduction techniques for data visualization
and their properties are reviewed. Thereby, the focus lies on an intuitive understanding of …
and their properties are reviewed. Thereby, the focus lies on an intuitive understanding of …
Approximated and user steerable tSNE for progressive visual analytics
N Pezzotti, BPF Lelieveldt… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Progressive Visual Analytics aims at improving the interactivity in existing analytics
techniques by means of visualization as well as interaction with intermediate results. One …
techniques by means of visualization as well as interaction with intermediate results. One …
Deepeyes: Progressive visual analytics for designing deep neural networks
Deep neural networks are now rivaling human accuracy in several pattern recognition
problems. Compared to traditional classifiers, where features are handcrafted, neural …
problems. Compared to traditional classifiers, where features are handcrafted, neural …
Parametric nonlinear dimensionality reduction using kernel t-SNE
Novel non-parametric dimensionality reduction techniques such as t-distributed stochastic
neighbor embedding (t-SNE) lead to a powerful and flexible visualization of high …
neighbor embedding (t-SNE) lead to a powerful and flexible visualization of high …
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
M Noviello, F Manfredi, E Ruggiero, T Perini… - Nature …, 2019 - nature.com
The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of …
for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of …