Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …

Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell
components into basic biomolecules, which are then recycled back into the cytosol. In this …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Autophagy is a membrane-mediated intracellular degradation system. The serine/threonine
kinase Atg1 plays an essential role in autophagosome formation. However, the role of the …

Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively
targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect …

Autophagy is a conserved cellular process for bulk degradation of intracellular protein and
organelles in lysosomes. In contrast to elegant studies of beclin1 using mouse models and …

According to the present view, metastasis marks the end in a sequence of genomic changes
underlying the progression of an epithelial cell to a lethal cancer. Here, we aimed to find out …

Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the
treatment of many estrogen receptor-positive breast cancers and have also proven to be …

Background: Compared with the general population, carriers of germline mutations in RB1
who survive retinoblastoma (ie, hereditary retinoblastoma survivors) are at increased risk of …

Introduction Breast cancers can be classified using whole genome expression into distinct
subtypes that show differences in prognosis. One of these groups, the basal-like subtype, is …