The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

The obesity pandemic continues unabated despite a persistent public health campaign to
decrease energy intake (“eat less”) and increase energy expenditure (“move more”). One …

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in
brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …

The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …