[HTML][HTML] Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?

Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

[HTML][HTML] Therapeutic strategies of glioblastoma (GBM): The current advances in the molecular targets and bioactive small molecule compounds

H Liu, W Qiu, T Sun, L Wang, C Du, Y Hu, W Liu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …

Regulated necrosis pathways: a potential target for ischemic stroke

K Ren, J Pei, Y Guo, Y Jiao, H Xing, Y Xie… - Burns & …, 2023 - academic.oup.com
Globally, ischemic stroke causes millions of deaths per year. The outcomes of ischemic
stroke are largely determined by the amount of ischemia-related and reperfusion-related …

Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition

M Borgini, P Wipf - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
Poly (ADP-ribose) polymerase (PARP) plays a key role in repairing DNA damage, and
several PARP inhibitors have been approved as treatments in BRCA1/2 mutated breast and …