Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Coronaviruses represent a large family of enveloped RNA viruses that infect a large
spectrum of animals. In humans, the severe acute respiratory syndrome coronavirus type 2 …

Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the
5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation …

The eIF4F complex regulates the cap-dependent mRNA translation process. It is becoming
increasingly evident that aberrant activity of this complex is observed in many cancers …

Small-molecule compounds that elicit mRNA-selective translation repression have attracted
interest due to their potential for expansion of druggable space. However, only a limited …

During eukaryotic translation initiation, the small ribosomal subunit, assisted by initiation
factors, locates the messenger RNA start codon by scanning from the 5′ cap. This process …