The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal
hypothalamus (MBH), but the components of this microgliosis and its metabolic …

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …

Objective Obesity and high fat diet (HFD) consumption in rodents is associated with
hypothalamic inflammation and reactive gliosis. While neuronal inflammation promotes HFD …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular
disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non …

Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis
are underlying causal components of diet-induced obesity in rodent models. This review …