1, 2, 4-Triazoles as important antibacterial agents

M Strzelecka, P Świątek - Pharmaceuticals, 2021 - mdpi.com
The global spread of drug resistance in bacteria requires new potent and safe antimicrobial
agents. Compounds containing the 1, 2, 4-triazole ring in their structure are characterised by …

Novel 1, 2, 4‐Triazoles as Antifungal Agents

Z Kazeminejad, M Marzi, A Shiroudi… - BioMed Research …, 2022 - Wiley Online Library
The development of innovative antifungal agents is essential. Some fungicidal agents are no
longer effective due to resistance development, various side effects, and high toxicity …

Antioxidant activity of 1, 2, 4-triazole and its derivatives: A mini-review

A Pachuta-Stec - Mini reviews in medicinal chemistry, 2022 - ingentaconnect.com
The information about the presence of free radicals in biological materials was given for the
first time about 70 years ago. Since then, numerous scientific studies have been conducted …

Design and synthesis of coumarin-triazole hybrids: biocompatible anti-diabetic agents, in silico molecular docking and ADME screening

VC Basappa, VH Kameshwar, K Kumara, DK Achutha… - Heliyon, 2020 - cell.com
The current study demonstrates the synthesis of coumarin-triazole hybrids 8 (ae) in four
steps starting from substituted salicylaldehyde 1 (ae), and diethyl malonate 2. The …

Conformational analysis and DFT investigations of two triazole derivatives and its halogenated substitution by using spectroscopy, AIM and molecular docking

VS Kumar, YS Mary, YS Mary, G Serdaroğlu… - Chemical Data …, 2021 - Elsevier
[(E)-(4-Hydroxybenzylidene) amino]-3-(4-chlorobenzyl)-1H-1, 2, 4-triazole-5 (4H)-thione
(HTH) and 4-[(E)-(4-Hydroxybenzylidene) amino]-3-(2-chlorobenzyl)-1H-1, 2, 4-triazole-5 …

Self-polishing antifouling coatings based on benzamide derivatives containing capsaicin

X Wang, Z Liu, X Jiang, L Yu - Marine Pollution Bulletin, 2022 - Elsevier
In this study, N-hydroxymethylbenzamide was alkylated with various aromatic compounds to
obtain five novel benzamide derivatives containing capsaicin (BDCC), and the BDCC were …

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1, 2, 4-triazole

Y Sameliuk, A Kaplaushenko… - … University Journal of …, 2022 - dergipark.org.tr
The purpose of this literature review was to systematize data from studies of the biological
activity of 1, 2, 4-triazole derivatives with substituents in positions 4 and 5. The authors set …

Biological Evaluation of 4-(1H-triazol-1-yl) benzoic Acid Hybrids as Antioxidant Agents: In Vitro Screening and DFT Study

HA Abuelizz, HAA Taie, AH Bakheit, M Marzouk… - Applied Sciences, 2021 - mdpi.com
Fourteen triazole benzoic acid hybrids were previously characterized. This work aimed to
screen their in vitro antioxidant activity using different assays, ie, DPPH (1, 1-diphenyl-1 …

First Synthesis of the Novel Triazolo[3,4-b][1,3,4]Thiadiazoles and Triazolo[3,4-b][1,3,4]Thiadiazines Linked Chromeno[2,3-b]Pyridine

MA Ibrahim, SA Al-Harbi, ES Allehyani… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Abstract The novel 3-(4-amino-5-thioxo-4, 5-dihydro-1 H-1, 2, 4-triazol-3-yl)-2 H-chromeno
[2, 3-b] pyridine-2, 5 (1 H)-dione (3) was efficiently synthesized from reaction of ethyl 2, 5 …

Glycerol based carbon sulfonic acid catalyzed synthesis, in silico studies and in vitro biological evaluation of isonicotinohydrazide derivatives as potent antimicrobial …

A Sethiya, D Joshi, A Manhas, N Sahiba, DK Agarwal… - Heliyon, 2023 - cell.com
The present pathway involves synthesis of isonicotinohydrazide derivatives using isoniazid
and diversely substituted aldehydes in the presence of EtOH and catalytic amount of …