Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

OA MacLean, S Lytras, S Weaver, JB Singer… - PLoS …, 2021 - journals.plos.org
Virus host shifts are generally associated with novel adaptations to exploit the cells of the
new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus …

The spread of the COVID‐19 coronavirus: Health agencies worldwide prepare for the seemingly inevitability of the COVID‐19 coronavirus becoming endemic

P Hunter - EMBO reports, 2020 - embopress.org
While air travel from and to China has subsided and cases of people infected with the
COVID-19 coronavirus appear all over the world, virologists, epidemiologists and public …

Why is temperature sensitivity important for the success of common respiratory viruses?

R Eccles - Reviews in medical virology, 2021 - Wiley Online Library
This review explores the idea that temperature sensitivity is an important factor in
determining the success of respiratory viruses as human parasites. The review discusses …

Breaking the cycle of malaria treatment failure

MF Boni - Frontiers in Epidemiology, 2022 - frontiersin.org
Treatment of symptomatic malaria became a routine component of the clinical and public
health response to malaria after the second world war. However, all antimalarial drugs …

Safety and upper respiratory pharmacokinetics of the hemagglutinin stalk-binding antibody VIS410 support treatment and prophylaxis based on population modeling …

AM Wollacott, MF Boni, KJ Szretter, SE Sloan… - …, 2016 - thelancet.com
Background Seasonal influenza is a major public health concern in vulnerable populations.
Here we investigated the safety, tolerability, and pharmacokinetics of a broadly neutralizing …

[HTML][HTML] Economic epidemiology of avian influenza on smallholder poultry farms

MF Boni, AP Galvani, AL Wickelgren… - Theoretical population …, 2013 - Elsevier
Highly pathogenic avian influenza (HPAI) is often controlled through culling of poultry.
Compensating farmers for culled chickens or ducks facilitates effective culling and control of …

Long-time behavior of a PDE replicator equation for multilevel selection in group-structured populations

DB Cooney, Y Mori - Journal of Mathematical Biology, 2022 - Springer
In many biological systems, natural selection acts simultaneously on multiple levels of
organization. This scenario typically presents an evolutionary conflict between the incentive …

[HTML][HTML] The impact of the highly virulent SARS-CoV-2 Gamma variant on young adults in the state of São Paulo: was it inevitable?

B Spira - Cureus, 2022 - ncbi.nlm.nih.gov
Background The coronavirus disease 2019 (COVID-19) pandemic had and is still having a
tremendous impact on people all over the world, but it has been particularly harsh in South …

Natural selection in the evolution of SARS-CoV-2 in bats, not humans, created a highly capable human pathogen

OA MacLean, S Lytras, S Weaver, JB Singer, MF Boni… - BioRxiv, 2020 - biorxiv.org
RNA viruses are proficient at switching host species, and evolving adaptations to exploit the
new host's cells efficiently. Surprisingly, SARS-CoV-2 has apparently required no significant …

Evolutionary epidemiology: preparing for an age of genomic plenty

OG Pybus, C Fraser, A Rambaut - … Transactions of the …, 2013 - royalsocietypublishing.org
Evolutionary epidemiology: preparing for an age of genomic plenty | Philosophical Transactions
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