Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …

Importance Loss-of-function mutations in the melatonin receptor are associated with insulin
resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Epigenetic modifications, including methylation or acetylation as well as post‐transcriptional
modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

Aging is an inevitable and multifactorial biological process. Free radicals have been
implicated in aging processes; it is hypothesized that they cause cumulative oxidative …

The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease,
including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia …

Dynamic aspects of melatonin's actions merit increasing future attention. This concerns
particularly entirely different effects in senescent, weakened oscillators and in dysregulated …

Melatonin is an indolamine synthesized in the pineal gland that has a wide range of
physiological functions, and it has been under clinical investigation for expanded …