The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

Background A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA
nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and …

Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …

IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding …

IgA vasculitis (IgAV) is an inflammation of small vessels caused by perivascular deposition
of IgA and activation of neutrophils. It may present as systemic vasculitis (IgAV-Henoch …

The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and
disease activity. While this has mainly been studied in the context of the bacterial …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …