Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
CB Mishra, M Tiwari, CT Supuran - Medicinal Research …, 2020 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
Primary open-angle glaucoma
RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
[HTML][HTML] PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons
WT Yan, WJ Zhao, XM Hu, XX Ban… - Neural regeneration …, 2023 - journals.lww.com
PANoptosis is a newly identified type of regulated cell death that consists of pyroptosis,
apoptosis, and necroptosis, which simultaneously occur during the pathophysiological …
apoptosis, and necroptosis, which simultaneously occur during the pathophysiological …
[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
The molecular basis of retinal ganglion cell death in glaucoma
M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …
results in visual field loss and irreversible blindness. A crucial element in the …
Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma
Y Miao, GL Zhao, S Cheng, Z Wang, XL Yang - Progress in retinal and eye …, 2023 - Elsevier
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …
Primary open-angle glaucoma
YH Kwon, JH Fingert, MH Kuehn… - New England Journal …, 2009 - Mass Medical Soc
Primary Open-Angle Glaucoma | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
[HTML][HTML] Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes
Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond
SA Lipton - Nature reviews Drug discovery, 2006 - nature.com
Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-d-
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …
[HTML][HTML] Neuronal death in glaucoma
HA Quigley - Progress in retinal and eye research, 1999 - Elsevier
Glaucoma is recognized to have its major detrimental effect upon the eye by killing retinal
ganglion cells. The process of cell death appears to be initiated at the optic nerve head …
ganglion cells. The process of cell death appears to be initiated at the optic nerve head …