The role of PARP1 in neurodegenerative diseases and aging
K Mao, G Zhang - The FEBS journal, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …
Focus on ferroptosis regulation: exploring novel mechanisms and applications of ferroptosis regulator
TL Ma, JX Chen, P Zhu, CB Zhang, Y Zhou, JX Duan - Life Sciences, 2022 - Elsevier
Ferroptosis is a kind of iron-dependent regulatory necrosis characterized by the fatal
accumulation of iron-dependent lipid peroxides in the plasma membrane and the final …
accumulation of iron-dependent lipid peroxides in the plasma membrane and the final …
Regulation of anoikis by extrinsic death receptor pathways
YH Han, Y Wang, SJ Lee, MH Jin, HN Sun… - Cell Communication and …, 2023 - Springer
Metastatic cancer cells can develop anoikis resistance in the absence of substrate
attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria …
attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria …
Small-molecule inhibitors of necroptosis: current status and perspectives
C Zhuang, F Chen - Journal of Medicinal Chemistry, 2019 - ACS Publications
Necroptosis, an important form of programmed cell death (PCD), is a highly regulated
caspase-independent type of cell death that plays a critical role in the pathophysiology of …
caspase-independent type of cell death that plays a critical role in the pathophysiology of …
Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms
TL Ma, Y Zhou, C Wang, L Wang… - Oxidative medicine …, 2021 - Wiley Online Library
Ferroptosis is an iron‐dependent regulated necrosis characterized by the peroxidation
damage of lipid molecular containing unsaturated fatty acid long chain on the cell …
damage of lipid molecular containing unsaturated fatty acid long chain on the cell …
Elucidation of Antiviral and Antioxidant Potential of C-Phycocyanin against HIV-1 Infection through In Silico and In Vitro Approaches
Antiretroviral therapy is the single existing therapy for patients infected with HIV; however, it
has drawbacks in terms of toxicity and resistance. Thus, there is a continuous need to …
has drawbacks in terms of toxicity and resistance. Thus, there is a continuous need to …
Elucidating the Influence of MPT-driven necrosis-linked LncRNAs on immunotherapy outcomes, sensitivity to chemotherapy, and mechanisms of cell death in clear …
J Huang, M Liu, H Chen, J Zhang, X Xie, L Jiang… - Frontiers in …, 2023 - frontiersin.org
Background Clear cell renal carcinoma (ccRCC) stands as the prevailing subtype among
kidney cancers, making it one of the most prevalent malignancies characterized by …
kidney cancers, making it one of the most prevalent malignancies characterized by …
Bioactivity screening of antarctic sponges reveals anticancer activity and potential cell death via ferroptosis by mycalols
Sponges are known to produce a series of compounds with bioactivities useful for human
health. This study was conducted on four sponges collected in the framework of the XXXIV …
health. This study was conducted on four sponges collected in the framework of the XXXIV …
RNA modifications act as regulators of cell death
L Xu, C Zhang, H Yin, S Gong, N Wu, Z Ren… - RNA biology, 2021 - Taylor & Francis
Currently, more than one hundred types of RNA modifications have been found, and many
of these modifications are reversible and dynamically regulated. RNA modifications can …
of these modifications are reversible and dynamically regulated. RNA modifications can …
[HTML][HTML] Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
J Chen, Y Wang, D Zhao, L Zhang, W Zhang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Among current novel druggable targets, protein–protein interactions (PPIs) are of
considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal …
considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal …