Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: From pathogenic factors to therapeutic targets

S Günther, P Fagone, G Jalce, AG Atanasov… - Drug discovery today, 2019 - Elsevier
Highlights•MIF acts cytokine, enzyme, endocrine hormone and chaperon-like molecule.•D-
DT, a member of the MIF family, exerts non-redundant effects from MIF.•MIF and D-DT are up …

Rediscovering MIF: new tricks for an old cytokine

J Harris, S VanPatten, NS Deen, Y Al-Abed… - Trends in …, 2019 - cell.com
Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic
cytokine with critical and supporting roles in many disease states and conditions. Its disease …

The multifaceted roles of NLRP3-modulating proteins in virus infection

J Harris, NA Borg - Frontiers in immunology, 2022 - frontiersin.org
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …

Exploring the anti‐inflammatory activity of sulforaphane

K Treasure, J Harris… - Immunology and Cell …, 2023 - Wiley Online Library
Dysregulation of innate immune responses can result in chronic inflammatory conditions.
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …

Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells

Z Xiao, S Song, D Chen, R van Merkerk… - Angewandte Chemie …, 2021 - Wiley Online Library
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …

[HTML][HTML] Molecular mechanisms and clinical application of Iguratimod: A review

H Jiang, H Gao, Q Wang, M Wang, B Wu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Iguratimod (IGU) is a novel small-molecule anti-rheumatic drug with remarkable
effectiveness and good safety for the treatment of active rheumatoid arthritis. Its mechanism …

[HTML][HTML] Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

K Mangano, E Mazzon, MS Basile, R Di Marco… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine
expressed by a variety of cell types. Although MIF has been primarily studied for its role in …

Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders

T Kok, AA Wasiel, RH Cool, BN Melgert… - Drug discovery today, 2018 - Elsevier
Highlights•MIF plays a key part in inflammatory diseases and cancer.•Many structural
scaffolds are available for MIF inhibition.•Not all studies provide proper assessment of MIF …

Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer

Y Wen, W Cai, J Yang, X Fu, L Putha, Q Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the
pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF …

Advances and insights for small molecule inhibition of macrophage migration inhibitory factor

V Trivedi-Parmar, WL Jorgensen - Journal of medicinal chemistry, 2018 - ACS Publications
Macrophage migration inhibitory factor (MIF) is an upstream regulator of the immune
response whose dysregulation is tied to a broad spectrum of inflammatory and proliferative …