Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: From pathogenic factors to therapeutic targets
S Günther, P Fagone, G Jalce, AG Atanasov… - Drug discovery today, 2019 - Elsevier
Highlights•MIF acts cytokine, enzyme, endocrine hormone and chaperon-like molecule.•D-
DT, a member of the MIF family, exerts non-redundant effects from MIF.•MIF and D-DT are up …
DT, a member of the MIF family, exerts non-redundant effects from MIF.•MIF and D-DT are up …
Rediscovering MIF: new tricks for an old cytokine
Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic
cytokine with critical and supporting roles in many disease states and conditions. Its disease …
cytokine with critical and supporting roles in many disease states and conditions. Its disease …
The multifaceted roles of NLRP3-modulating proteins in virus infection
The innate immune response to viruses is critical for the correct establishment of protective
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
adaptive immunity. Amongst the many pathways involved, the NLRP3 [nucleotide-binding …
Exploring the anti‐inflammatory activity of sulforaphane
K Treasure, J Harris… - Immunology and Cell …, 2023 - Wiley Online Library
Dysregulation of innate immune responses can result in chronic inflammatory conditions.
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …
Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …
play key roles in inflammation and cancer. Current strategies to develop small molecule …
[HTML][HTML] Molecular mechanisms and clinical application of Iguratimod: A review
H Jiang, H Gao, Q Wang, M Wang, B Wu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Iguratimod (IGU) is a novel small-molecule anti-rheumatic drug with remarkable
effectiveness and good safety for the treatment of active rheumatoid arthritis. Its mechanism …
effectiveness and good safety for the treatment of active rheumatoid arthritis. Its mechanism …
[HTML][HTML] Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach
K Mangano, E Mazzon, MS Basile, R Di Marco… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Abstract Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine
expressed by a variety of cell types. Although MIF has been primarily studied for its role in …
expressed by a variety of cell types. Although MIF has been primarily studied for its role in …
Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders
Highlights•MIF plays a key part in inflammatory diseases and cancer.•Many structural
scaffolds are available for MIF inhibition.•Not all studies provide proper assessment of MIF …
scaffolds are available for MIF inhibition.•Not all studies provide proper assessment of MIF …
Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer
Y Wen, W Cai, J Yang, X Fu, L Putha, Q Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the
pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF …
pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF …
Advances and insights for small molecule inhibition of macrophage migration inhibitory factor
V Trivedi-Parmar, WL Jorgensen - Journal of medicinal chemistry, 2018 - ACS Publications
Macrophage migration inhibitory factor (MIF) is an upstream regulator of the immune
response whose dysregulation is tied to a broad spectrum of inflammatory and proliferative …
response whose dysregulation is tied to a broad spectrum of inflammatory and proliferative …