Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Cancer is the second most common cause of death in the United States, trailing only heart
disease in incidence. Despite significant worldwide investment in research, cancer remains …

Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC)
characterized by the presence of abundant extracellular mucin which accounts for at least …

Cancer is one of the leading causes of death in the United States along with heart disease.
The hallmark of cancer treatment has been conventional chemotherapy. Chemotherapeutic …

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell
(CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct …

Suppression of dendritic cell function in cancer patients is thought to contribute to the
inhibition of immune responses and disease progression. Molecular mechanisms of this …