Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …

Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral
administration, including GI transfer, motility, pH and GI fluid volume and composition. An in …

The Magenstrasse (stomach road) describes the fast emptying of ingested liquids from the
postprandial stomach. The occurrence of the Magenstrasse has great importance for drugs …

Over the past few decades, physiologically based biopharmaceutics modeling (PBBM) has
demonstrated its utility in both new drug and generic product development. Applications of …

The application of in silico modeling to predict the in vivo outcome of an oral drug product is
gaining a lot of interest. Fully relying on these models as a surrogate tool requires …