Malaria is possibly the most serious infectious disease of humans, infecting 5–10% of the
world's population, with 300–600 million clinical cases and more than 2 million deaths …

Severe malaria is manifest by a variety of clinical syndromes dependent on properties of
both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most …

In light of the recent controversies over the role of animal models for research into the
development of new treatments for severe malaria, particularly cerebral disease, a group of …

In male vertebrates, two conflicting paradigms—the energetic costs of high dominance rank
and the chronic stress of low rank—have been proposed to explain patterns of immune …

Severe malarial anemia (SMA) is the most frequent life-threatening complication of malaria
and may contribute to the majority of malarial deaths worldwide. To explore the mechanisms …

The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for
its high mortality are poorly understood. Studies indicate that host mediators produced …

Malaria is the most important parasitic disease worldwide, responsible for an estimated 225
million clinical cases each year. It mainly affects children, pregnant women and non-immune …

T cell-mediated inflammatory immune responses contribute to both the clearance and
pathology of malaria infections; the host's ability to down-regulate inflammation once …

We report the first trial of candidate malaria vaccine antigen FMP1, a 42kDa fragment from
the C-terminus of merozoite surface protein-1 (MSP-1) from the 3D7 strain of Plasmodium …

Severe malarial anemia (SMA) in semi-immune individuals eliminates both infected and
uninfected erythrocytes and is a frequent fatal complication. It is proportional not to …