This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Preclinical drug development studies currently rely on costly and time-consuming animal
testing because existing cell culture models fail to recapitulate complex, organ-level disease …

Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main
features of acute lung injury in animal models. A Committee was organized to determine the …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive
proteins are known, none of them in vertebrates. By employing a candidate-gene approach …

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical
treatments available. The generation of myofibroblasts, which are critical for fibrogenesis …