Objective To test the hypothesis that ApoE isoforms affect mitochondrial structure and
function that are related to cognitive impairment in Alzheimer disease (AD), we …

Few discoveries have influenced drug discovery programs more than the finding that
mitochondrial membranes undergo swings in permeability in response to cellular …

Deciphering the factors causing damage to white matter fiber bundles and exploring new
strategies to alleviate white matter injury (WMI) is a promising treatment to improve …

Aim White matter damage (WMD) is the main cause of cerebral palsy and cognitive
impairment in premature infants. Although caffeine has been shown to possess …

Selective targeting of sodium channel subtypes Nav1. 7, Nav1. 8, and Nav1. 9, preferentially
expressed by peripheral nociceptors, represents a unique opportunity to develop analgesics …

Background Reducing neuroinflammatory damage is an effective strategy for treating white-
matter damage (WMD) in premature infants. Caffeine can ameliorate hypoxia–ischemia …

The glucagon‐like peptide 1 (GLP‐1) is a hormone which is produced in the
enteroendocrine L‐cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in …

During the onset of neuropathic pain from a variety of etiologies, nociceptors become
hypersensitized, releasing neurotransmitters and other factors from centrally-projecting …

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder that is
associated with learning, memory, and cognitive deficits. Neuroinflammation and synapse …

Dexpramipexole (DEX) has been described as the first-in-class F1Fo ATP synthase activator
able to boost mitochondrial bioenergetics and provide neuroprotection in experimental …