Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

The urinary tract comprises the renal pelvis, the ureter, the urinary bladder, and the urethra.
The tract acts as a functional unit, first propelling urine from the kidney to the bladder, then …

Unlike the intense research effort devoted to exploring the significance of heparanase in
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …

Objective Fetal megacystis generally presents as suspected lower urinary tract obstruction
(LUTO), which is associated with severe perinatal morbidity. Genetic etiologies underlying …

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause
of chronic kidney disease in the first three decades of life, and in utero obstruction to urine …

LRIG1, leucine-rich repeats and immunoglobulin-like domains protein 1, was discovered
more than 20 years ago and has been shown to be downregulated or lost, and to function as …

Summary The Urofacial or Ochoa Syndrome (UFS or UFOS) is characterized by an inverted
facial expression (those affected seem crying while smiling) associated with lower urinary …

Urofacial (also called Ochoa) syndrome (UFS) is an autosomal recessive congenital
disorder of the urinary bladder featuring voiding dysfunction and a grimace upon smiling …

Heparanase is highly implicated in tumor metastasis due to its capacity to cleave heparan
sulfate and, consequently, remodel the extracellular matrix underlying epithelial and …

Urofacial syndrome (UFS; also known as Ochoa syndrome) is characterized by prenatal or
childhood onset of urinary bladder voiding dysfunction, abnormal facial movement with …