Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

Mechanical forces are essential to the development and progression of fibrosis, and are
likely to be as important as soluble factors. These forces regulate the phenotype and …

From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …

Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress,
compression, differential tissue rigidity and strain, to which they adapt by engaging …

The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …

The capability to directly interrogate intracellular structures inside a single cell for
measurement and manipulation is important for understanding subcellular and suborganelle …