Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of
multiple human conditions including neurodegenerative diseases. Mitochondria are …

Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …

Abstract Changes in mitochondrial size and shape have been implicated in several
physiologic processes, but their role in mitochondrial Ca 2+ uptake regulation and overall …

The cellular mechanisms responsible for aging are poorly understood. Aging is considered
as a degenerative process induced by the accumulation of cellular lesions leading …