The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

The neuronal ceroid lipofuscinoses (NCLs), collectively known as Batten disease, are a
group of neurological diseases that affect all ages and ethnicities worldwide. There are 13 …

Dictyostelium discoideum is one of eight non‐mammalian model organisms recognized by
the National Institute of Health for the study of human pathology. The use of this slime mould …

The CLN3 gene was identified over two decades ago, but the primary function of the CLN3
protein remains unknown. Recessive inheritance of loss of function mutations in CLN3 are …

Abstract Ceroid lipofuscinosis neuronal 5 (CLN5) is a member of a family of proteins that are
linked to neuronal ceroid lipofuscinosis (NCL). This devastating neurological disorder …

The social amoeba Dictyostelium discoideum has been a preferred model organism during
the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family
of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At …

Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3
disease) is a lysosomal storage disease characterized by progressive blindness, seizures …

Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5
disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work …