Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial
chemistry complementary to enzymatic reactions, enabling the selective labelling of …

The transformational impact of bioorthogonal chemistries has inspired new strategies for the
in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts …

Bioorthogonal transformations are chemical reactions that use pathways which biological
processes do not access. Bioorthogonal chemistry provides new approaches for imaging …

Therapeutic nanoreactors are of increasing interest in precise cancer therapy, which have
been explored to in situ produce therapeutic compounds from inert prodrugs or intrinsic …

Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …

Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Bioorthogonal catalysis using transition-metal catalysts (TMCs) provides a toolkit for the in
situ generation of imaging and therapeutic agents in biological environments. Integrating …

In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …