[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
Cell-based therapy for degenerative retinal disease
M Zarbin - Trends in molecular medicine, 2016 - cell.com
Stem cell-derived retinal pigment epithelium (RPE) and photoreceptors (PRs) have restored
vision in preclinical models of human retinal degenerative disease. This review discusses …
vision in preclinical models of human retinal degenerative disease. This review discusses …
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
K Achberger, C Probst, J Haderspeck, S Bolz, J Rogal… - elife, 2019 - elifesciences.org
The devastating effects and incurable nature of hereditary and sporadic retinal diseases
such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa …
such as Stargardt disease, age-related macular degeneration or retinitis pigmentosa …
[HTML][HTML] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …
seq) at key fetal stages and follow the development of the major cell types as well as …
[HTML][HTML] Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids
CM Fligor, SS Lavekar, J Harkin, PK Shields… - Stem Cell Reports, 2021 - cell.com
The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …
events to specify the organization of varied cell types, including the elongation of axons from …
Three-dimensional retinal organoids facilitate the investigation of retinal ganglion cell development, organization and neurite outgrowth from human pluripotent stem …
Retinal organoids are three-dimensional structures derived from human pluripotent stem
cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving …
cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving …
Morphological and molecular defects in human three-dimensional retinal organoid model of X-linked juvenile retinoschisis
X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a
degenerative retinopathy with a retinal splitting phenotype. We generated human induced …
degenerative retinopathy with a retinal splitting phenotype. We generated human induced …
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease
SS Lavekar, J Harkin, M Hernandez, C Gomes… - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …
Stepwise differentiation of retinal ganglion cells from human pluripotent stem cells enables analysis of glaucomatous neurodegeneration
Human pluripotent stem cells (hPSCs), including both embryonic and induced pluripotent
stem cells, possess the unique ability to readily differentiate into any cell type of the body …
stem cells, possess the unique ability to readily differentiate into any cell type of the body …
[HTML][HTML] Organoid technology for retinal repair
A major cause for vision impairment and blindness in industrialized countries is the loss of
the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main …
the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main …