There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of
multicellular organisms. Proper cellular response to changes in oxygen tension during …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid
infections, amputations and life-threatening complications, DFUs often respond poorly to …

The processes by which cells sense and respond to ambient oxygen concentration are
fundamental to cell survival and function, and they commonly target gene regulatory events …

High altitude exposes humans to hypobaric hypoxia, which induces various physiological
and molecular changes. Recent studies point toward interaction between circadian rhythms …

Ischemic stroke is a leading cause of disability and mortality worldwide due to the narrow
therapeutic window of the only approved therapies like intravenous thrombolysis and …

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on
TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts …