Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface
groups, are currently attracting a lot of interest in biological fields owing to their fluorescent …

Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and
xenobiotics across the plasma membrane in various tissues throughout the human body …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …

Simple Summary The effectiveness and safety of the anti-cancer agent doxorubicin
(anthracycline group medicine) depend on the metabolism and retention of the drug in the …

The dose‐dependent cardiomyopathy of adriamycin (doxorubicin) limits its long‐term
clinical use, which is revealed as a consequence of cardiomyocyte ferroptosis. As a ferrous …

Ferroptosis is an iron-dependent cell death and contributes to doxorubicin-induced
cardiotoxicity, but the mechanisms behind intracellular iron overload in cardiomyocyte after …

Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …