Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

[HTML][HTML] Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research

EK Elmahallawy, AAM Alkhaldi, AA Saleh - Biomedicine & …, 2021 - Elsevier
Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Leishmania Immunity: Advancing Immunotherapy and Vaccine Development

NM Ikeogu, GN Akaluka, CA Edechi, ES Salako… - Microorganisms, 2020 - mdpi.com
Parasitic diseases still constitute a major global health problem affecting billions of people
around the world. These diseases are capable of becoming chronic and result in high …

Toxoplasma gondii-induced neutrophil extracellular traps amplify the innate and adaptive response

FJB Miranda, BC Rocha, MCA Pereira, LMN Pereira… - Mbio, 2021 - Am Soc Microbiol
Toxoplasmosis affects one-third of the human population worldwide. Humans are accidental
hosts and are infected after consumption of undercooked meat and water contaminated with …

Neutrophils and Visceral Leishmaniasis: Impact on innate immune response and cross‐talks with macrophages and dendritic cells

M Kupani, RK Pandey… - Journal of Cellular …, 2021 - Wiley Online Library
Neutrophils with their array of microbicidal activities are the first innate immune cells to
guard against infection. They are also most crucial for the host's initial defense against …

Approved drugs successfully repurposed against Leishmania based on machine learning predictions

R Oualha, YZ Abdelkrim, I Guizani… - Frontiers in Cellular …, 2024 - frontiersin.org
Drug repurposing is a promising approach towards the discovery of novel treatments against
Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing …

Distinct neutrophil effector functions in response to different isolates of Leishmania aethiopica

E Adem, E Cruz Cervera, E Yizengaw, Y Takele… - Parasites & …, 2024 - Springer
Abstract Background In Ethiopia, cutaneous leishmaniasis is mainly caused by Leishmania
(L.) aethiopica parasites and presents in three main clinical forms. It is still not clear if the …

Paradoxical immune response in leishmaniasis: The role of toll‐like receptors in disease progression

IE Bamigbola, S Ali - Parasite immunology, 2022 - Wiley Online Library
Abstract Toll‐like receptors (TLRs), members of pattern recognition receptors, are expressed
on many cells of the innate immune system, and their engagements with antigens regulate …

Leishmania infantum Axenic Amastigotes Induce Human Neutrophil Extracellular Traps and Resist NET-Mediated Killing

TKF Oliveira, J Oliveira-Silva… - Tropical Medicine and …, 2023 - mdpi.com
Neutrophils are multifaceted cells that, upon activation, release meshes of chromatin
associated with different proteins, known as neutrophil extracellular traps (NETs) …

Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica

N Masoudzadeh, M Östensson, J Persson… - Scientific reports, 2020 - nature.com
Anthroponotic cutaneous leishmaniasis (CL) caused by Leishmania tropica (L. tropica)
represents a public health challenge in several resource poor settings. We herein employed …