Hsp90 is one of the most important chaperones involved in regulating the maturation of
more than 300 client proteins, many of which are closely associated with refractory diseases …

Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …

Mice that could be highly repopulated with human hepatocytes would have many potential
uses in drug development and research applications. The best available model of liver …

Hepatitis C virus (HCV) causes liver-related death in more than 300,000 people annually.
Treatments for patients with chronic HCV are suboptimal, despite the introduction of directly …

The emergence of antiviral drug-resistant mutants is the most important issue in current
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …

To gain insights into the functions of a viral RNA replicase, we have assembled in vitro and
entirely from nonplant sources, a fully functional replicase complex of Tomato bushy stunt …

Infectious organisms have to cope with demanding and rapidly changing environments
during establishment in the host. This is particularly relevant for pathogens that utilize …

The viral RNA polymerase complex of influenza A virus consists of three subunits PB1, PB2
and PA. Recently, the cellular chaperone Hsp90 was shown to play a role in nuclear import …

Ebola virus (EBOV), a negative-sense RNA virus in the family Filoviridae, is known to cause
severe hemorrhagic fever in humans and other primates. Infection with EBOV causes a high …

Plus-stranded RNA viruses coopt host proteins to promote their robust replication in infected
hosts. Tomato bushy stunt tombusvirus (TBSV) is a model virus that can replicate a small …