Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene
expression at single-cell resolution, which greatly revolutionizes transcriptomic studies. A …

Alternative splicing is a tightly regulated biological process by which the number of gene
products for any given gene can be greatly expanded. Genomic variants in splicing …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which
is produced by oligodendrocytes (OLs). We performed single-cell transcriptomic analysis of …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the
number of tools designed to analyse these data has dramatically increased. Navigating the …

Rapid cost drops and advancements in next-generation sequencing have made profiling of
cells at individual level a conventional practice in scientific laboratories worldwide. Single …

Single-cell RNAseq and alternative splicing studies have recently become two of the most
prominent applications of RNAseq. However, the combination of both is still challenging …

A major limitation of RNA sequencing (RNA-seq) analysis of alternative splicing is its
reliance on high sequencing coverage. We report DARTS (https://github …

High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene
expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing …