Silk fibroin has applications in different medical fields such as tissue engineering,
regenerative medicine, drug delivery and medical devices. Advances in silk chemistry and …

Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

Current treatment strategies for osteoarthritis (OA) predominantly address symptoms with
limited disease-modifying potential. There is a growing interest in the use of adipose-derived …

In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers
for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell …

Bone is a dynamic organ with high regenerative potential and provides essential biological
functions in the body, such as providing body mobility and protection of internal organs …

Silk, a natural biopolymer, has been used clinically as suture material over thousands of
years and has received much impetus for a plethora of biomedical applications in the last …

Cartilage tissue engineering has primarily focused on the generation of grafts to repair
cartilage defects due to traumatic injury and disease. However engineered cartilage tissues …

Bone tissue engineering has mainly focused on generating 3D grafts to repair bone defects.
However, the underlying signaling mechanisms responsible for development of such 3D …

To date, the development of phenotypically stable, functionally equivalent engineered
cartilage tissue constructs remains elusive. This study explored chondrogenic differentiation …

Osteoarthritis (OA) is a musculoskeletal disease characterized by progressive degeneration
of osteochondral tissues. Current treatment is restricted to the reduction of pain and loss of …