Silk chemistry and biomedical material designs
Silk fibroin has applications in different medical fields such as tissue engineering,
regenerative medicine, drug delivery and medical devices. Advances in silk chemistry and …
regenerative medicine, drug delivery and medical devices. Advances in silk chemistry and …
Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment
M Bhattacharjee, JL Escobar Ivirico… - Proceedings of the …, 2022 - National Acad Sciences
Current treatment strategies for osteoarthritis (OA) predominantly address symptoms with
limited disease-modifying potential. There is a growing interest in the use of adipose-derived …
limited disease-modifying potential. There is a growing interest in the use of adipose-derived …
Single-cell RNA-seq analysis of cells from degenerating and non-degenerating intervertebral discs from the same individual reveals new biomarkers for intervertebral …
H Cherif, M Mannarino, AS Pacis, J Ragoussis… - International journal of …, 2022 - mdpi.com
In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers
for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell …
for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell …
Stem cell-friendly scaffold biomaterials: applications for bone tissue engineering and regenerative medicine
Y Zhang, D Wu, X Zhao, M Pakvasa… - … in bioengineering and …, 2020 - frontiersin.org
Bone is a dynamic organ with high regenerative potential and provides essential biological
functions in the body, such as providing body mobility and protection of internal organs …
functions in the body, such as providing body mobility and protection of internal organs …
Insight into silk-based biomaterials: from physicochemical attributes to recent biomedical applications
Silk, a natural biopolymer, has been used clinically as suture material over thousands of
years and has received much impetus for a plethora of biomedical applications in the last …
years and has received much impetus for a plethora of biomedical applications in the last …
Tissue engineering strategies to study cartilage development, degeneration and regeneration
Cartilage tissue engineering has primarily focused on the generation of grafts to repair
cartilage defects due to traumatic injury and disease. However engineered cartilage tissues …
cartilage defects due to traumatic injury and disease. However engineered cartilage tissues …
Osteogenic signaling on silk-based matrices
Bone tissue engineering has mainly focused on generating 3D grafts to repair bone defects.
However, the underlying signaling mechanisms responsible for development of such 3D …
However, the underlying signaling mechanisms responsible for development of such 3D …
Regulation of chondrogenesis and hypertrophy in silk fibroin-gelatin-based 3D bioprinted constructs
S Chameettachal, S Midha… - ACS Biomaterials Science …, 2016 - ACS Publications
To date, the development of phenotypically stable, functionally equivalent engineered
cartilage tissue constructs remains elusive. This study explored chondrogenic differentiation …
cartilage tissue constructs remains elusive. This study explored chondrogenic differentiation …
Overcoming the dependence on animal models for osteoarthritis therapeutics–the promises and prospects of in vitro models
Osteoarthritis (OA) is a musculoskeletal disease characterized by progressive degeneration
of osteochondral tissues. Current treatment is restricted to the reduction of pain and loss of …
of osteochondral tissues. Current treatment is restricted to the reduction of pain and loss of …