Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Regenerative therapy for the Cornea

A Kumar, H Yun, ML Funderburgh, Y Du - Progress in retinal and eye …, 2022 - Elsevier
The cornea is the outmost layer of the eye, unique in its transparency and strength. The
cornea not only transmits the light essential for vision, also refracts light, giving focus to …

3D-printed PCL/PPy conductive scaffolds as three-dimensional porous nerve guide conduits (NGCs) for peripheral nerve injury repair

S Vijayavenkataraman, S Kannan, T Cao… - … in bioengineering and …, 2019 - frontiersin.org
Conductivity is a desirable property of an ideal nerve guide conduit (NGC) that is being
considered for peripheral nerve regeneration. Most of the conductive polymers reported in …

Biomimetic corneal stroma for scarless corneal wound healing via structural restoration and microenvironment modulation

J Huang, T Jiang, J Li, J Qie, X Cheng… - Advanced …, 2024 - Wiley Online Library
Corneal injury‐induced stromal scarring causes the most common subtype of corneal
blindness, and there is an unmet need to promote scarless corneal wound healing. Herein …

[HTML][HTML] Growth factors: Bioactive macromolecular drugs for peripheral nerve injury treatment–Molecular mechanisms and delivery platforms

T Wan, FS Zhang, MY Qin, HR Jiang, M Zhang… - Biomedicine & …, 2024 - Elsevier
Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and
Drug Administration (FDA), have found successful application in clinical practice. They hold …

Neural crest-like stem cells for tissue regeneration

J Soto, X Ding, A Wang, S Li - Stem Cells Translational …, 2021 - academic.oup.com
Neural crest stem cells (NCSCs) are a transient population of cells that arise during early
vertebrate development and harbor stem cell properties, such as self-renewal and …

The role of teratogens in neural crest development

S Cerrizuela, GA Vega‐Lopez… - Birth Defects Research, 2020 - Wiley Online Library
The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent
migratory embryonic cell population that generates a remarkably diverse and important …

Embryonic stem cells in development and regenerative medicine

A Doğan - Cell Biology and Translational Medicine, Volume 1 …, 2018 - Springer
After progressive improvement in embryonic stem (ES) cell field, several studies have been
conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal …

Transplantation of human induced pluripotent stem cell-derived neural crest cells for corneal endothelial regeneration

Y Gong, H Duan, X Wang, C Zhao, W Li… - Stem Cell Research & …, 2021 - Springer
Background The corneal endothelium maintains corneal hydration through the barrier and
pump function, while its dysfunction may cause corneal edema and vision reduction …

Directed differentiation of human pluripotent stem cells towards corneal endothelial-like cells under defined conditions

P Grönroos, T Ilmarinen, H Skottman - Cells, 2021 - mdpi.com
The most crucial function of corneal endothelial cells (CEnCs) is to maintain optical
transparency by transporting excess fluid out of stroma. Unfortunately, CEnCs are not able to …