Machine learning in bioprocess development: from promise to practice

LM Helleckes, J Hemmerich, W Wiechert… - Trends in …, 2023 - cell.com
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

When bioprocess engineering meets machine learning: A survey from the perspective of automated bioprocess development

N Duong-Trung, S Born, JW Kim… - Biochemical …, 2023 - Elsevier
Abstract Machine learning (ML) is becoming increasingly crucial in many fields of
engineering but has not yet played out its full potential in bioprocess engineering. While …

[HTML][HTML] Combining multi-fidelity modelling and asynchronous batch Bayesian Optimization

JP Folch, RM Lee, B Shafei, D Walz, C Tsay… - Computers & Chemical …, 2023 - Elsevier
Bayesian Optimization is a useful tool for experiment design. Unfortunately, the classical,
sequential setting of Bayesian Optimization does not translate well into laboratory …

[HTML][HTML] Digitally enabled approaches for the scale up of mammalian cell bioreactors

MK Alavijeh, I Baker, YY Lee, SL Gras - Digital Chemical Engineering, 2022 - Elsevier
With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …

Developing high-dimensional machine learning models to improve generalization ability and overcome data insufficiency for mixed sugar fermentation simulation

XY Huang, TJ Ao, X Zhang, K Li, XQ Zhao… - Bioresource …, 2023 - Elsevier
Biorefinery can be promoted by building accurate machine learning models. This work
proposed a strategy to enhance model's generalization ability and overcome insufficient …

[HTML][HTML] Applications of machine learning in antibody discovery, process development, manufacturing and formulation: Current trends, challenges, and opportunities

TT Khuat, R Bassett, E Otte, A Grevis-James… - Computers & Chemical …, 2024 - Elsevier
While machine learning (ML) has made significant contributions to the biopharmaceutical
field, its applications are still in the early stages in terms of providing direct support for quality …

Deep learning radiomics for the assessment of telomerase reverse transcriptase promoter mutation status in patients with glioblastoma using multiparametric MRI

H Zhang, H Zhang, Y Zhang, B Zhou… - Journal of Magnetic …, 2023 - Wiley Online Library
Background Studies have shown that magnetic resonance imaging (MRI)‐based deep
learning radiomics (DLR) has the potential to assess glioma grade; however, its role in …

[HTML][HTML] A review and perspective on hybrid modelling methodologies

AM Schweidtmann, D Zhang, M von Stosch - Digital Chemical Engineering, 2023 - Elsevier
The term hybrid modeling refers to the combination of parametric models (typically derived
from knowledge about the system) and nonparametric models (typically deduced from data) …

A comparative evaluation of machine learning algorithms for predicting syngas fermentation outcomes

GW Roell, A Sathish, N Wan, Q Cheng, Z Wen… - Biochemical …, 2022 - Elsevier
Clostridium carboxidivorans can use syngas to produce acids and alcohols. However,
simulating gas fermentation dynamics remains challenging. This study employed data …

A monitoring method for surface roughness of γ-TiAl alloy based on deep learning of time–frequency diagram

Y Wu, L Liu, L Huang, Z Wang - The International Journal of Advanced …, 2023 - Springer
Abstract γ-TiAl alloy is a typically difficult material to machine, with common machining
defects such as grain pull-out and material spalling during machining, resulting in …