Target based chemotherapeutic advancement of ruthenium complexes

BK Kundu, S Mukhopadhyay - Coordination Chemistry Reviews, 2021 - Elsevier
Over the last few years, great emphasis has been given to develop ruthenium complexes to
act as target specified chemotherapeutic agents. Indeed, there are few reviews available …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

J Qin, N Gong, Z Liao, S Zhang, P Timashev, S Huo… - Nanoscale, 2021 - pubs.rsc.org
Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer …

Ru (II), Ir (III), Re (I) and Rh (III) based complexes as next generation anticancer metallopharmaceuticals

U Das, B Kar, S Pete, P Paira - Dalton Transactions, 2021 - pubs.rsc.org
Several anticancer drugs such as cisplatin, and its analogues, epirubicin, and doxorubicin
are well known for their anticancer activity but the therapeutic value of these drugs comes …

Ruthenium (II)‐Dithiocarbazates as Anticancer Agents: Synthesis, Solution Behavior, and Mitochondria‐Targeted Apoptotic Cell Death

G Sahu, SA Patra, S Lima, S Das… - … A European Journal, 2023 - Wiley Online Library
The reaction of the Ru (PPh3) 3Cl2 with HL1− 3− OH (− OH stands for the oxime hydroxyl
group; HL1− OH= diacetylmonoxime‐S‐benzyldithiocarbazonate; HL2− OH …

LVVO-Ethyl Maltol-Based Metallodrugs (L2– = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis

G Sahu, SA Patra, PD Pattanayak… - Inorganic …, 2023 - ACS Publications
Four new oxidovanadium [VVOL1–4 (ema)] complexes (1–4) have been synthesized using
tridentate binegative ONO donor ligands H2L1–4 [H2L1:(E)-N′-(2-hydroxybenzylidene) …

Expanding the limits of photodynamic therapy: the design of organelles and hypoxia-targeting nanomaterials for enhanced photokilling of cancer

IR Calori, H Bi, AC Tedesco - ACS Applied Bio Materials, 2021 - ACS Publications
Photodynamic therapy (PDT) is a minimally invasive clinical protocol that combines a
nontoxic photosensitizer (PS), appropriate visible light, and molecular oxygen for cancer …

Platinum (II)-Metallaclip-Based theranostics for cell imaging and synergetic chemotherapy–photodynamic therapy

Y Wang, R Tang, D Wang, J Wang, Y Huang… - Inorganic …, 2022 - ACS Publications
Supramolecular coordination complexes formed by coordination-induced assembly not only
avoid the loss of activity of precursors but also provide an efficient way for controlled release …

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M= Fe (III), Ni (II), Cu (II) and Ru (III))–A …

C Pandya, A Sivaramakrishna - International Journal of Biological …, 2024 - Elsevier
Many terpyridines and their metal complexes are known to exhibit remarkable potential for
the interaction of biological targets. Notably, a subtle change in the structure of the ligand …

Luminescent 11-{Naphthalen-1-yl} dipyrido [3, 2-a: 2′, 3′-c] phenazine-Based Ru (II)/Ir (III)/Re (I) Complexes for HCT-116 Colorectal Cancer Stem Cell Therapy

U Das, S Shanavas, AH Nagendra, B Kar… - ACS Applied Bio …, 2023 - ACS Publications
Due to a number of unpleasant considerations, marketed drugs have steadily lost their
importance in the treatment of cancer. In order to find a viable cancer cell diagnostic agent …