The past twenty five years have seen an explosion in the creation and discovery of new
medicinal agents. Related innovations in drug delivery systems have not only enabled the …

Chronic non-healing wounds are major healthcare challenges that affect a noticeable
number of people; they exert a severe financial burden and are the leading cause of limb …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Purpose The aim of the study is to determine the effect of experimental parameters on
microinfusion through hollow microneedles into skin to optimize drug delivery protocols and …

The efficient and safe delivery of therapeutic proteins is the key to commercial success and,
in some cases, the demonstration of efficacy in current and future biotechnology products …

Morphine, the most widely used mu-opioid analgesic for acute and chronic pain, is the
standard against which new analgesics are measured. A thorough understanding of the …

Morphine is the most practical and versatile analgesic for the relief of severe pain associated
with advanced cancer. Information is available in the literature about its use in routine …

We recently developed an in vitro testing system, namely, ESCAR (Emulator of
SubCutaneous Absorption and Release). The objective of this work was to investigate drug …

Protein and peptide drugs are used for treatment of a variety of ailments. However, their
wider use has been hindered by issues such as poor bioavailability in vivo and the cost …

Background Oral and subcutaneous morphine is widely used for the treatment of cancer-
related pain; however, solid pharmacokinetic data on this practice are lacking. Furthermore …