Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age
and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and …

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer
therapy. However,< 50% of patients have an objective response, and nearly all patients …

Thromboembolic events are complications in cancer patients and hypercoagulability has
been linked to the tissue factor (TF) pathway, making this an attractive target. Here, we …

Abstract Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells.
The associated cytostasis has been shown to be reversible and cells escaping senescence …

Interconnected, fundamental aging processes are central to many illnesses and diseases.
Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli …

Aim: Existing targeted therapies for hepatocellular carcinoma (HCC) are resistant and have
limitations. It is crucial to find new HCC-related target genes. Methods: RNA-sequencing …

Aging exhibits several hallmarks in common with cancer, such as cellular senescence,
dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades …

Abstract The University of North Carolina Symposia on Hemostasis began in 2002, with “The
First Symposium on Hemostasis with a Special Focus on FVIIa and Tissue Factor.” They …