Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Adequate 24-h BP control presently offers the most feasible intervention for reducing
glomerular BP transmission and improving suboptimal outcomes in CKD. Investigations …

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly
gaining recognition and this is a comprehensive review of early and recent publications in …

Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Experiments tested the hypothesis that P2 receptor reactivity is impaired in angiotensin
(Ang) II hypertensive rats fed an 8% NaCl diet (Ang II+ HS). Juxtamedullary afferent …

Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension,
yet very limited data are available describing the resulting blood pressure-renal blood flow …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

ANG II is thought to increase the susceptibility to hypertension-induced renal disease (HIRD)
via blood pressure (BP)-dependent and BP-independent pathways; however, the …

Autoregulation is critical for protecting the kidney against arterial pressure elevation and is
compromised in some forms of hypertension. Evidence indicates that activated lymphocytes …

ATP is an essential energy substrate for cellular metabolism, but it can also influence many
biological processes when released into the extracellular milieu. Research has established …