Abstract Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

Summary RLR-mediated type I IFN production plays a pivotal role in elevating host immunity
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the
invasion of pathogens and initiate host antimicrobial responses such as the production of …

INTRODUCTION Sensing of pathogenic microbes and tissue damage by the innate immune
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …

Cytosolic double-stranded DNA (dsDNA) stimulates the production of type I interferon (IFN)
through the endoplasmic reticulum (ER)–resident adaptor protein STING (stimulator of IFN …