Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …

Gene drive is a naturally occurring phenomenon in which selfish genetic elements
manipulate gametogenesis and reproduction to increase their own transmission to the next …

Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …

Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …

Background Gene drives based on CRISPR-Cas9 technology are increasingly being
considered as tools for reducing the capacity of mosquito populations to transmit malaria …

Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …

Malaria is among the world's deadliest diseases, predominantly affecting Sub-Saharan
Africa and killing over half a million people annually. Controlling the principal vector, the …

Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …