Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities

V Laizé, PJ Gavaia, ML Cancela - Drug Discovery Today: Disease Models, 2014 - Elsevier
This review discusses the suitability and advantages of teleost fish for studying underlying
mechanisms of normal and pathological development and mineralization of vertebrate …

The role of FHL2 in wound healing and inflammation

V Wixler - The FASEB Journal, 2019 - Wiley Online Library
ABSTRACT The 4‐and‐a‐half LIM domain protein 2 (FHL2) is a multifunctional adaptor
protein that can interact with cell surface receptors, cytosolic adaptor and structural proteins …

SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling

NV Jordan, A Prat, AN Abell… - … and cellular biology, 2013 - Am Soc Microbiol
We previously identified a gene signature predicted to regulate the epithelial-mesenchymal
transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic …

Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer

L Verset, J Tommelein, X Moles Lopez… - British journal of …, 2013 - nature.com
Background: Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal
adhesion structures and has been suggested to have a role in cancer progression. It has …

Status, challenges, and perspectives of fish cell culture—Focus on cell lines capable of in vitro mineralization

V Laizé, JT Rosa, M Tarasco, ML Cancela - Cellular and molecular …, 2022 - Elsevier
Sixty years after the development of the first piscine cell line, more than 700 cell lines have
been established from a wide range of fish species and tissues. The fast provision of in vitro …

Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer

L Al-Nomani, J Friedrichs, R Schüle, R Büttner… - … -Research and Practice, 2015 - Elsevier
Background Four and a half LIM domain protein-2 (FHL2) is part of the focal adhesion
structures modulating cell motility. FHL2 may translocate into the nucleus serving as a …

Four and a half LIM domain protein 2 enhances differentiation and mineralization of human dental pulp cells

X Tian, Q Wang, X Wang - Journal of Endodontics, 2015 - Elsevier
Introduction Four and a half LIM domain protein 2 (FHL2) is 1 member of the LIM-only
protein family, which is a transcriptional cofactor, playing important roles in osteoblast …